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Euregio Cardiovascular International Research Training Group GRK1508 (EuCAR) 'Arterial Remodeling'

The Euregio Cardiovascular International Research Training Group (EuCAR) builds on the unique asset of a close proximity (< 30 km) and an extensive and complementary network of bilateral collaborations between the RWTH Aachen and Maastricht Universities. Given the enormous significance of cardiovascular disease for morbidity and mortality in western societies, the EuCAR research program is focused on the underlying macrovascular pathobiology and pathophysiology of Arterial Remodeling, namely athero­sclerosis and plaque destabilization, but also therapeutic arteriogenesis and arterial tissue engineering. A main goal is to introduce novel and relevant cellular and molecular targets from related fields, e.g. immune mediators and growth factors (Nature Med 2007;13:587, Nature Rev Immunol 2007;7:467, Circulation 2007;115:2516, Circulation 2008;117:70, Circ Res 2008;102:209). The scientific environment of EuCAR is endorsed by the DFG Forschergruppe 809 'Chemokines and Adhesion Molecules in Cardiovascular Pathogenesis' and the DFG SFB542 'Molecular Mechanisms of Inflammation'.

EuCAR-Overview (3.5MB)

In a bilateral approach, each project is supervised by a professor and tenure-track assistant each from Aachen and Maastricht, implementing individual mentoring and qualification profiles. The teaching program is based on the PhD and MD/PhD programs in Aachen and Maastricht and linked by specific modules, soft skill training, master classes, lecture series, international annual workshops and an eLearning platform. Fulfilling publication criteria and credit point requirements, successful graduates will receive a double degree (German Dr. rer.nat. and Dutch PhD).

PhD positions

P1 Gene profiling of unstable atherosclerotic plaques
Supervisors: Zenke / Daemen, Assistant: Cleutgens
G1-M-G2
P2 Mast cells in arterial plaque destabilization
Supervisors: Weber / Biessen, Assistant: Zernecke
G1-AC
P3 Matrix Gla-protein (MGP) and arterial calcifications in fetuin-A-/- mice
Supervisors: Jahnen-Dechent / Floege / Vermeer, Assistant: Schurgers
G1-AC
P4 Two-photon microscopy for cell imaging in atherosclerotic arteries
Supervisors: Uhlig / Post, van Zandvoort
G1-M-G2
P5 Shedding of proatherogenic mediators from vascular cells
Supervisors: Ludwig / Hackeng, Assistant: Koenen
G1-M
P6 The role of IKKs in atherosclerosis
Supervisors: Bernhagen / Weber / de Winther, Assistant: Zernecke
G1-AC
P7 Molecular mechanisms of platelet microparticle formation
Supervisors: Weber / Heemskerk, Assistants: Cauwenberghs/Koenen
G1-M
P8 Differential effects of angiogenic growth factors in monocyte subsets
Supervisors: Weber / Trautwein / Waltenberger, Assistants: Hristov
G1-AC-G2
P9 The CD40/CD40L axis in arterial neointima formation
Supervisors: Weber / Daemen, Assistant: Lutgens
G1-M
P10 Role of the complement cascade in arterial injury
Supervisors: Weber / Buurman, Assistant: Shagdarsuren
G1-AC
P11 Arterialization of vein grafts in uremia
Supervisors: Floege / Jacobs, Assistant: Koeppel
G1-M-G2
P12 Cytoprotective effects of nitrite in ischemia / reperfusion injury
Supervisors: Kelm / Buurman, Assistant: Rassaf
G-AC
P13 MIF as a CXCR ligand in vasculogenesis and therapeutic collateral growth/arteriogenesis
Supervisors: Bernhagen / Post, Assistant: Liehn
G1-AC
P14 Arterial tissue engineering: improving endothelial integrity and function
Supervisors: Schmitz-Rode / Kelm / Post, Assistant: Jockenhövel
G1-AC-G2